Progress in laboratory testing of thyroid disease

Research

Summary of activities to collect information about concerns and potential risks associated with changes in reference intervals for free thyroxine and TSH and about communication and interactions among relevant stakeholders

The C-STFT under the leadership Prof. Linda Thienpont, Dr. Jim Faix, and Dr. Graham Beastall performed broad initiatives world-wide to create awareness about harmonization and standardization of TSH and fT4 assays among assay manufacturers, clinical laboratories, endocrinologists, physicians, and patients. The C-STFT collected information from these stakeholders from 2014-2016 on how changes in assay calibration are communicated to laboratories and physicians, on concerns by...

Seasonal changes in serum TSH concentrations observed from a big dataset obtained during 6 consecutive years from 2010 to 2015 at a single hospital in Japan.

Yoshihara A, Noh J, Watanabe N, Iwaku K, Kunii Y, Ohye H, Suzuki M, Matsumoto M, Suzuki N, Sugino K, Thienpont L, Hishinuma A, Ito K. Thyroid 2018;28:429-436.

Standardization of free thyroxine measurements paves the way for the adoption of a more uniform reference interval

De Grande LAC, Van Uytfanghe K, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P, Thienpont LM on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1642-52.

Harmonization of serum thyroid-stimulating hormone measurements paves the way for the adoption of a more uniform reference interval.

Thienpont LM, Van Uytfanghe K, De Grande LAC, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1248-60.

Using "big data" to describe the effect of seasonal variation in thyroid-stimulating hormone.

De Grande LA, Goossens K, Van Uytfanghe K, Halsall I, Yoshimura Noh J, Hens K, Thienpont LM. Clin Chem Lab Med 2017;55:e34-e36.

Monitoring the stability of the standardization status of FT4 and TSH assays by use of daily outpatient medians and flagging frequencies.

De Grande LA, Goossens K, Van Uytfanghe K, Das B, MacKenzie F, Patru MM, Thienpont LM; IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chim Acta. 2017;467:4-18.

Standardization of Thyroid Tests The future standardization of FT4 and harmonization of TSH measurements in serum. A request for input on benefits and risks from Thyroid Foundations.

Thienpont LM, Faix JD, Beastall G. ThyroWorld Volume 18 Summer 2015; 13-4.

Standardization of Free Thyroxine and Harmonization of Thyrotropin Measurements: A Request for Input from Endocrinologists and Other Physicians.

Thienpont LM, Faix JD, Beastall G. Thyroid 2015;25:1379-80. Clin Endocrinol (Oxf) 2016;84:305-6. Endocr J 2015;62:855-6. Exp Clin Endocrinol Diabetes 2016;124:61-2. Endocrine 2015;50:826-7. Eur Thyroid J 2015;4:217-2. Endocr Pract 2016;22:374.

A Fresh Look at the Relationship between TSH and Free Thyroxine in Cross-Sectional Data.

De Grande LAC, Van Uytfanghe K, Thienpont LM. Eur Thyroid J 2015;4:69-70.

A Progress report of the IFCC Committee for Standardization of Thyroid Function Tests.

Thienpont LM, Van Uytfanghe K, Van Houcke S, Das B, Faix JD, MacKenzie F, Quinn FA, Rottmann M, Van den Bruel A. Eur Thyroid J 2014;3:109-116.

Time to standardize thyroid function testing.

Thienpont LM, van Uytfanghe K. The Pathologist 2014; Nov: 29-27 ( www.thepathologist.com ).

A "Step-Up" approach for harmonization.

Van Uytfanghe K, De Grande LA, Thienpont LM. Clin Chim Acta 2014;432:62-67.

A statistical basis for harmonization of thyroid stimulating hormone immunoassays using a robust factor analysis model.

Stöckl D, Van Uytfanghe K, Van Aelst S, Thienpont LM. Clin Chem Lab Med 2014;52:965-72.

Thyroid-Stimulating Hormone. Why efforts to harmonize testing are critical to patient care.

Faix JD, Thienpont LM. Clin Labor News 2013;39 no. 5.

Pages